[18F]scyllo-1

[18F]scyllo-1 is a fluorine-18 labeled radiopharmaceutical based on the scyllo-inositol isomer, developed as a diagnostic imaging agent for Positron Emission Tomography (PET). It is one of a series of fluorinated inositol derivatives synthesized to exploit the altered inositol metabolism and transport often observed in malignant tissues, such as breast cancer. The molecule consists of a scyllo-inositol core modified with a propyl linker bearing the 18F isotope. In preclinical evaluations using breast tumor-bearing mouse models, it was tested for its ability to accumulate in malignant tissue, though it demonstrated lower tumor uptake compared to its isomer [18F]myo-2. The tracer is synthesized via automated radiosynthesis and is intended to provide a non-invasive means of monitoring tumor progression or response to therapy by targeting inositol transporters.

Other names

18F-scyllo-1scyllo-1-propyl-18Fscyllo1-propyl-18Fscyllo 1-propyl-18F